Product Description
The ZORBAX SB-C8 4.6 × 75 mm 3.5 µm column is engineered for high-performance liquid chromatography (HPLC) in analytical laboratories requiring compact columns with high resolution. With a fully porous 3.5 µm particle size, 80 Å pore size and a reversed-phase C8 bonded phase, this column provides excellent separation of moderately non-polar compounds while offering low acidity and minimal metal content to reduce analyte interaction with metal surfaces. It supports operation up to 400 bar and is optimized for versatility in LC workflows including small molecule and impurity separations. The column’s compact dimensions (4.6 mm internal diameter × 75 mm length) make it well-suited for faster turnaround times, higher throughput and smaller solvent consumption – a great choice for everyday method development and routine analyses.
Key Features & Specifications
| Parameter | Value |
|---|---|
| Manufacturer | Agilent Technologies |
| Manufacturer Part No. | 866953-906 |
| Brand | ZORBAX Rx |
| Phase | SB-C8 (C8 bonded reversed-phase) |
| Internal Diameter (ID) | 4.6 mm |
| Column Length | 75 mm |
| Particle Size | 3.5 µm |
| Pore Size | 80 Å |
| Carbon Load | 5.5% |
| Endcapped | No |
| Guard Column Included | No |
| Hardware | Conventional |
| Operating Pressure | Up to 400 bar |
| Separation Mode | Reversed Phase |
| Molecular Weight Range | 0 to 3000 Da |
| pH Range | 1 – 8 |
| Maximum Temperature | 40 °C at pH 6-8; 80 °C at pH 1-6 |
Applications & Use-Cases
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Separation and quantification of moderately non-polar organic compounds in pharmaceuticals, environmental, food & beverage, or chemical-analysis labs.
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High-throughput analytics where column length reduction (75 mm) helps speed up separations and save solvent.
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Method development workflows for reversed-phase LC requiring a mid-polarity C8 phase (versus more non-polar C18) for improved peak shapes or faster elution of certain analytes.
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Quality control (QC) routine analyses where reliability, reproducibility, and minimal metal-content interactions are important.
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Impurity profiling, degradant analysis, or any workflow where analytes span moderate polarity and one desires robust performance under standard HPLC pressures.
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